Antibody engineering workflow combining ANARCI, BioPhi, IgFold, FoldX, and Rosetta tools through SciMiner.
Security Analysis
high confidenceThe skill's requirements, instructions, and included files are consistent with an orchestration wrapper around SciMiner for antibody engineering and do not request unrelated credentials or perform unexpected actions.
The name and description claim orchestration of ANARCI, BioPhi, IgFold, FoldX, and Rosetta via SciMiner. The skill only requires a SCIMINER_API_KEY and the code provides a registry mapping SciMiner tool endpoints to expected parameters — this is proportionate to the stated purpose.
SKILL.md instructs the agent to call SciMiner endpoints for sequence numbering, humanization, structure prediction, relaxation, scoring, and design, and to upload antibody sequences and PDB files as needed. The instructions do not direct the agent to read unrelated system files, to collect additional credentials, or to transmit data to unknown endpoints beyond SciMiner.
There is no install spec (instruction-only skill) and the included Python files are small and declarative (a registry). No downloads, archive extraction, or package installs are performed by the skill itself.
Only SCIMINER_API_KEY is required and declared as the primary credential, which matches the runtime instructions that call SciMiner APIs. No unrelated secrets or system config paths are requested.
always is false and the skill does not request system-wide configuration or elevated persistence. The agent may invoke the skill autonomously (platform default), which is expected for a service integration.
Guidance
This skill sends antibody sequences and structure files to SciMiner using your SCIMINER_API_KEY. Only install it if you trust SciMiner and understand the data-sharing/privacy implications: do not upload proprietary or regulated sequences unless permitted. Treat the API key like a secret (rotate it if exposed) and verify SciMiner's security/privacy policy. Because the skill can be invoked by the agent, be cautious about allowing unattended/autonomous runs with your key enabled.
Latest Release
v1.0.1
**Expanded with Rosetta-guided design and developability profiling for antibody engineering.** - Added Rosetta FastRelax, SAP Score, FastDesign, and InterfaceAnalyzer tools for advanced structure relaxation, aggregation risk assessment, precision redesign, and interface analysis. - Updated workflow to include structure relaxation after modeling, SAP hydrophobicity screening, and Rosetta-based precision design phases. - Clarified boundaries and integration between ANARCI/BioPhi (sequence), IgFold/FoldX (structure/energy), and Rosetta (refinement/scoring). - Emphasized multi-objective prioritization balancing affinity, stability, immunogenicity, and aggregation risk. - Updated tool descriptions and recommended workflow for new and expanded Rosetta integrations.
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